Lithium Orotate Nasal Spray
4.9 · 2187 reviews90 days to feel the difference. No results? Full refund and you keep the bottle. No returns, no questions.
Your brain contains lithium naturally. It depletes as you age.
Kinase regulation.
GSK-3β is one of the most ancient signaling regulators in biology. Left unchecked, it accelerates tau phosphorylation and the accumulation of amyloid proteins. Trace lithium promotes its natural inhibition at concentrations matching what the brain maintains physiologically.
Neurogenesis support.
At trace concentrations, lithium promotes BDNF expression in the hippocampus, the region most responsible for memory encoding and spatial cognition. TRACE delivers at the dose the brain was designed to receive through diet and water, not the dose used in psychiatry.
Stress axis modulation.
Persistent HPA-axis activation raises cortisol, which impairs hippocampal neurogenesis over time. Trace lithium helps modulate CRH signaling, supporting the brain's natural resilience against the cumulative burden of chronic stress.
Lithium Orotate
Not all lithium forms are equal. Lithium carbonate and lithium chloride, the forms used in psychiatry, require high doses to achieve therapeutic blood levels because they cross into the brain inefficiently. Lithium orotate uses orotic acid as its carrier molecule, which is believed to facilitate passage across the blood-brain barrier more effectively, allowing meaningful concentrations at a fraction of the dose. It is the specific form Harvard used in their 2025 Nature study. Sublingual delivery compounds the advantage. Sprayed under the tongue and held for 30 seconds, the compound absorbs directly through the dense blood vessel network in the sublingual mucosa into systemic circulation, bypassing the digestive tract and the liver metabolism that degrades oral supplements. More of the active compound arrives where it needs to go, at the trace concentration the brain actually maintains.
"Lithium deficiency and the onset of Alzheimer's disease."
A decade-long study led by Dr. Bruce Yankner at Harvard Medical School found that lithium was the only trace metal significantly depleted in the brains of people with mild cognitive impairment and Alzheimer's disease. When the team restricted lithium in healthy mice, it dramatically accelerated amyloid-beta plaque formation, neurofibrillary tangle accumulation, microglial inflammation, and cognitive decline — all hallmarks of Alzheimer's. When they restored it using lithium orotate at doses far below psychiatric concentrations, those changes reversed. Mice treated for nearly their entire adult lives showed no evidence of toxicity. Lead Researcher: Dr. Bruce Yankner, Harvard Medical School · Publication: Nature, Vol. 645, August 6, 2025 · Form studied: Lithium Orotate at physiological trace dose.
Two sprays.
Administer 2 sprays sublingually. Each spray delivers 1mg lithium orotate. The orotate salt form is selected for its ability to cross biological membranes efficiently.
Hold 30 seconds.
Hold under the tongue for 30 seconds before swallowing. Sublingual delivery bypasses first-pass hepatic metabolism for better utilization of the active compound.
Once daily.
Morning or evening. Consistent daily use supports the trace element equilibrium the brain maintains over time. Trace element biology is cumulative, not acute. A daily practice is the unit of measurement, not a single dose.
265+ biological processes that rely on lithium.
From stem cell maintenance and circadian signaling to sleep architecture and fertility pathways. Lithium is not a single-target compound. It is foundational infrastructure that modern diets largely stopped delivering. The breadth comes from two master regulators: GSK-3β, which has over 100 known direct substrates and has been conserved across roughly 500 million years of evolution, and inositol monophosphatase, which sits at the center of a separate signaling cascade. Lithium inhibits both. The 265 is the downstream count, not the direct interaction count. One trace element. Two ancient switches. Cascading consequences in both directions.
"After the Harvard paper dropped I spent weeks looking for a lithium orotate product worth taking. The spray format and the orotate form are exactly right. Four weeks in and my sleep is different. Sharper mornings. I am not stopping."
Marcus T. · 44
Verified buyer
"I have taken magnesium, zinc, copper, all of it. Nobody was talking about lithium as a trace nutrient until recently. Once I understood the GSK-3 mechanism I wanted to try it. Week six the clarity shift was real."
Jennifer K. · 51
Verified buyer
"The sublingual delivery matters. I tried a lithium orotate capsule from another brand and felt nothing. This is noticeably different. Sleep quality went up first, then everything else followed."
David R. · 47
Verified buyer
"My integrative medicine doctor mentioned the Harvard study before I even found TRACE. She said lithium orotate at trace levels was worth looking at. Six weeks in and I agree. Energy is steadier and mornings feel cleaner."
Sarah M. · 53
Verified buyer
"Not a stimulant, not a nootropic in the conventional sense. A quiet but real shift in baseline. Sleep is deeper. Focus holds longer. The only thing I changed was this."
Robert L. · 49
Verified buyer
"Took about three weeks before I noticed anything meaningful. Then sleep quality improved noticeably and my afternoon energy stopped dropping off. Worth the patience."
Christine B. · 45
Verified buyer
"I have been researching lithium orotate since the Nature publication. Most products are capsule form at doses that do not match what the research used. TRACE is the only sublingual orotate spray I found at the right dose."
Thomas H. · 58
Verified buyer
"Two sprays every morning. I barely think about it until I notice how different the day feels by afternoon. Sharper, steadier, less reactive to stress. Three months in and I am not going back."
Amanda P. · 46
Verified buyer
"I started this after watching a family member's cognitive health decline. I do not make claims about what it will or will not prevent. I just know the research pointed me here and I feel noticeably better."
Michael C. · 52
Verified buyer
Try TRACE for 90 days — or keep it free.
Use it every day for 90 days. If you do not feel a real difference in your cognitive clarity, sleep quality, and stress resilience, email us and we will refund every penny. You keep the bottle. No returns, no forms, no questions. We make this offer because trace element supplementation works when delivered correctly, and most people notice the shift long before 90 days.
No. Pharmaceutical lithium is prescribed at 600 to 1200mg per day for mood disorders. TRACE delivers 2mg lithium orotate per serving, which is consistent with what occurs naturally in the human brain and what researchers define as a trace dietary level. These are entirely different concentration regimes with different safety profiles and different mechanisms.
Sublingual spray bypasses first-pass hepatic metabolism, meaning more active compound reaches systemic circulation before breakdown. Lithium orotate is already the most bioavailable lithium salt. Sublingual delivery builds on that advantage, allowing meaningful physiological concentrations at lower total elemental dose.
Lithium orotate uses orotic acid as its transport molecule, which is thought to facilitate passage across the blood-brain barrier more efficiently than inorganic salts like carbonate or chloride. It is the specific form Harvard used in their 2025 Nature study and why meaningful brain-level concentrations are achievable at much lower elemental doses.
TRACE supports foundational neurological processes rather than acute stimulation, so onset is gradual. Most people report changes in sleep quality within the first two to four weeks. Effects related to cognitive clarity and stress resilience tend to accumulate over 60 to 90 days of consistent daily use. This is not a stimulant with a same-day onset.
At trace dietary concentrations, lithium orotate has a well-characterized safety profile supported by population-level epidemiology and the 2025 Harvard mouse data, which found no evidence of toxicity in animals treated for nearly their entire adult lives. People with kidney conditions, thyroid disorders, or existing prescription lithium should consult a physician before use.
At trace concentrations, significant interactions with common supplements are unlikely. Known pharmaceutical interactions with lithium involve diuretics, NSAIDs, and certain medications that affect kidney function or sodium balance. If you take prescription medications in any of those categories, consult your physician before starting TRACE.
Use TRACE daily for 90 days. If you do not feel a meaningful difference, email us for a full refund. Nothing to ship back, no forms, no questions. You keep the bottle either way.
- Aron L, Ngian ZK, Qiu C, et al. Lithium deficiency and the onset of Alzheimer's disease. Nature. 2025;645:712-721. doi:10.1038/s41586-025-09335-x
- Forlenza OV, Diniz BS, Radanovic M, et al. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment. Br J Psychiatry. 2011;198(5):351-356.
- Kessing LV, Gerds TA, Knudsen NN, et al. Association of lithium in drinking water with the incidence of dementia. JAMA Psychiatry. 2017;74(10):1005-1010.
- Nunes MA, Viel TA, Buck HS. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alzheimer Res. 2013;10(1):104-107.
- Machado-Vieira R, Manji HK, Zarate CA. The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar Disord. 2009;11(Suppl 2):92-109.
- Nehls M. The Conspiracy Against Lithium. Skyhorse Publishing; 2025.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Referenced research describes lithium, GSK-3β inhibition, and trace element biology generally and does not represent studies conducted on this specific product.